Study of analgesic effects of topical tramadol on Osteoarthritis pain

Study of analgesic effects of topical tramadol 5% on Osteoarthritis pain: A randomized, placebo control, double blind clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201609143014N14

Enrollment

Registered

2016-12-22

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoartritis. Polyarthrosis, Coxarthrosis [arthrosis of hip], Gonarthrosis [arthrosis of knee], Arthrosis of first carpometacarpal joint, Other arthrosis

Interventions

Intervention 1: Intervention: Tramadol 5% cream, twice daily for one month. Intervention 2: Control: Cream without active ingredient, twice daily for one month.

Treatment - Drugs

Intervention: Tramadol 5% cream, twice daily for one month

Control: Cream without active ingredient, twice daily for one month

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patient with moderate and severe osteoartritis pain Exclusion criteria: Patients with hypersensitivity reaction to tramadol; Patient with history of seizure; Patients taking oral anticonvulsant drug

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Before intervention; One month after intervention. Method of measurement: Visual analog scale.	—

Secondary

Measure	Time frame
Side effects. Timepoint: After intervention. Method of measurement: quality Questionnarie.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Shahram Ala

Mazandaran University of Medical Science, Faculty of Pharmacy

sala@mazums.ac.ir+98 11 3354 3082

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026