The effect of vitamin D3 and calcium supplementation in treatment of postpartum depression

The effect of vitamin D3 and calcium supplementation on depression severity, levels of 25-hydroxy vitamin D, sex hormone estradiol and inflammatory biomarkers (Interleukin 6,Tumor Necrosis Factor alpha) in women with postpartum depression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016091416123N9

Enrollment

Registered

2017-05-21

Start date

2017-07-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post partum depression. Mild mental and behavioural disorders associated with the puerperium

Interventions

Intervention 1: 50000 IU pearl vitamin D3, every 14 days + 500 milligram calcium carbonate tablet, daily, for 8 weeks. Intervention 2: 50000 IU pearl vitamin D3, every 14 days + calcium carbonate plac

Treatment - Drugs

50000 IU pearl vitamin D3, every 14 days + 500 milligram calcium carbonate tablet, daily, for 8 weeks

50000 IU pearl vitamin D3, every 14 days + calcium carbonate placebo, daily, for 8 weeks

Pearl paraffin as vitamin D placebo, every 14 days + calcium carbonate placebo, daily, for 8 weeks

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Body mass index (BMI) less than 35; age 45 to 18 years; earning a score of 12 and above in Edinburgh questionnaire? period range from 1 month until 6 months after child birth. Exclusion criteria: Normal or above normal range for vitamin D levels; chronic diseases such as diabetes, renal failure, gastrointestinal diseases, liver, thyroid, kidney stones and cancer in the past 5 years; birth abnormalities; taking contraceptive drugs; endocrine disorders; severe depression and other mental disorders; using antidepressants.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Tumor Necrosis Factor alpha. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;Interleukin 6. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;Estradiol. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;25 Hydroxy Vitamin D. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;Depression severity. Timepoint: Baseline and every 14 days for 8 weeks. Method of measurement: Edinburgh questionnaire.;Serum calcium. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.	—

Measure

Time frame

Tumor Necrosis Factor alpha. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;Interleukin 6. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;Estradiol. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;25 Hydroxy Vitamin D. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.;Depression severity. Timepoint: Baseline and every 14 days for 8 weeks. Method of measurement: Edinburgh questionnaire.;Serum calcium. Timepoint: Before and after of 8 weeks intervention. Method of measurement: seum level.

—

Secondary

Measure	Time frame
Weight. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Scales.;Body Fat Percentage. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Fat analyzer.;Waist Circumference. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: inflexible meter.;Body Mass Index. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Using the formula.	—

Measure

Time frame

Weight. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Scales.;Body Fat Percentage. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Fat analyzer.;Waist Circumference. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: inflexible meter.;Body Mass Index. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Using the formula.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSima Jafarirad

Ahvaz Jundishapur University of Medical Sciences

sjafarirad@gmail.com+61 3367543

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026