Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: Participants in the intervention group will receive a topical formulation containing garden cress (Lepidium sativum) seed extract. The medication will be applied tw
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: "Patients aged 40 years and older with primary knee osteoarthritis who present with mild to moderate knee joint pain (up to a maximum score of 7 on the Visual Analogue Scale [VAS]), and whose diagnosis of osteoarthritis has been confirmed based on the American College of Rheumatology (ACR) criteria. Patients with no prior history of joint replacement No history of acute or uncontrolled conditions such as gastrointestinal bleeding, uncontrolled hypertension, or myocardial and cerebrovascular infarctions within the past six months, etc. No use of nonsteroidal anti-inflammatory drugs (NSAIDs) or oral corticosteroids within 14 days prior to the study, and no use of injectable forms within 30 days prior to the study BMI<35Kg/m^2
Exclusion criteria
Exclusion criteria: Hypersensitivity to the plant or its constituents Occurrence of an unexpected adverse effect Low patient recruitment and lack of cooperation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: At baseline, and at 14 and 28 days after the start of treatment. Method of measurement: VAS score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Joint stiffness. Timepoint: At baseline, and at 28 days after the start of treatment. Method of measurement: WOMAC scale.;Assessment of physical functioning and the ability to perform activities of daily living. Timepoint: At baseline, and at 28 days after the start of treatment. Method of measurement: WOMAC scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyde Sedighe Yousefi
Mazandaran University of Medical Sciences
Outcome results
None listed