Severe and Refractory Lupus Nephritis. Systemic lupus erythematosus with organ or system involvement
Conditions
Interventions
Intervention 1: Intervention group: systemic (intravenous) transplantation of Adipose-derived Mesenchymal Stem Cell to patient (2 millions/Kg). Intervention 2: control group: No cell transplantation w
Treatment - Other
Intervention group: systemic (intravenous) transplantation of Adipose-derived Mesenchymal Stem Cell to patient (2 millions/Kg).
control group: No cell transplantation with conventional treatment regimens
Sponsors
Council for Stem Cell Sciences and Technologies
Ferdowsi Uiniversity of Mashhad
Iranian Academic Center for Education, Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Criteria for entrance to the study: Criteria for entrance to the study include increase in proteinuria (defined as more than 1.0 g of protein excretion in a 24-h urine specimen), Systemic lupus erythematosus disease activity index of more than 8 (All patients were resistant to at least 3 months of therapy with conventional treatment standard). Exclusion criteria: uncontrolled infection, failure of kidney or other vital organs, pregnancy or lactating.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteinuria. Timepoint: 1 week, 1, 3, 6, 9 and 12 months. Method of measurement: clinical tests.;Glomerular filtration rate. Timepoint: 1 week, 1, 3, 6, 9 and 12 months. Method of measurement: clinical tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systemic lupus erythematosus disease activity index score. Timepoint: 1 week, 1, 3, 6, 12 and 18 months. Method of measurement: clinical tests. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZhaleh Shariati-Sarabi
Department ofInternal Medicine, Mashhad University of Medical Sciences
Outcome results
None listed