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Ondansetron effect on headache after spinal anesthesia

Compare the effect of two different doses of ondansetron in the prevention of headache after spinal anesthesia in pregnant women referred to Taleghani Hospital in Arak

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016090629732N1
Enrollment
180
Registered
2017-07-12
Start date
2016-02-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post spinal Punctur Headache. Other complications of spinal and epidural anaesthesia during the puerperium

Interventions

Intervention 1: Group II: 4 mg of ondansetron with its volume to 5 ml of normal saline has to be encoded and then intravenously 5 minutes before the operation. Intervention 2: Group III: 5 mL of salin
Treatment - Drugs
Group II: 4 mg of ondansetron with its volume to 5 ml of normal saline has to be encoded and then intravenously 5 minutes before the operation.
Group III: 5 mL of saline for 5 minutes before surgery is encoded and then administered intravenously.
Group I: ondansetron 8 mg with 5 ml of normal saline to have its volume is then encoded and intravenously administered 5 minutes before the operation.

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA 1-2; aged 20 to 35 years; patient satisfaction; no history of cardiovascular disease; avoiding the use of selective serotonin reuptake inhibitors and opioids; non preeclampsia and eclampsia; no history of migraine; body mass index less 30 exclusion criteria: history of cardiovascular disease; migraine headaches; use of selective serotonin reuptake inhibitors; ondansetron and sensitivity to local anesthetics and contraindications of spinal anesthesia; the patient's lack of cooperation; piercing the dura more than once; the need to serve an incomplete spinal anesthesia drugs

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Headache. Timepoint: 24 Hour, 48 Hour, 4 Day, 7Day. Method of measurement: Mild, Moderate, Severe Based on Standard questionnaires.;Nausea. Timepoint: 24 Hour, 48 Hour, 4 Day, 7Day. Method of measurement: Based on the score of specified ago.;Vomitting. Timepoint: ?24 Hour, 48 Hour, 4 Day, 7Day?. Method of measurement: Based on the score of specified ago.

Secondary

MeasureTime frame
Blood pressure. Timepoint: Every 5 minutes to 30 minutes after spinal anesthesia. Method of measurement: By strain gauges attached to the monitor.;Heart beat. Timepoint: Every 5 minutes to 30 minutes after spinal anesthesia. Method of measurement: By pulse oximeter attached to the monitor.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesamodin Modir

Arak University of Medical Sciences

modir@arakmu.a.c.ir+98 34173505

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026