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The effect of Vitamin C on salivary antioxidant level in patients with bruxism (gnash)

The effectiveness of Vitamin C on the Level of Salivary Total Antioxidant Capacity(TAC) in bruxism patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160903029651N2
Enrollment
30
Registered
2018-03-04
Start date
2017-08-23
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bruxism. Any other disorders of sensation, function and behaviour, not due to physical disorders, which are not mediated through the autonomic nervous system, which are limited to specific systems or parts of the body, and which are closely associated in time with

Interventions

Intervention 1: Chewing Vitamin C 250 mg/day with the taste of cherry of Osweh Company? chew one of them daily for a month in the morning (30 days). Intervention 2: Chewing Placebo (Similst to Vitami

Sponsors

International Campus Branch, Tehran University of Medical Sciences, School of Dentistry
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Our diagnostic criteria for bruxism is considered based on ICSD-R: 1. Symptoms indicating grinding teeth on each other while sleeping 2. Abnormal grinding of teeth 3. Sound of grinding teeth 4. Discomfort of jaw muscle As well as other symptoms stated by Murali: 1. Toothpicking 2. Fatigue of masticatory muscles 3. Recurrent migraines 4. Broken Dental fillings or splint 5.Ulceration of denture underlying mucosa 6. Sensitivity to percussion 7. Increase in the size of the Temporal and Masseter muscles

Exclusion criteria

Exclusion criteria: Those who have the following features are removed from the list: 1. Record of severe trauma and dental surgeries 2. Clinical record of functional disorder (depression and anxiety)and sleep disorders (Apnea and Insomnia) 3. Moderate to high consumption of alcohol and cigarettes 4. Systemic problems (diseases of kidney and liver, thyroid and diabetes) and cancer, pregnant and nursing mothers 5. Taking drugs (Glucocorticoids or Selective Serotonin, edible contraceptives, variety of Antioxidants,Folic acid, Allopurinol such as Zenthine Oxidase Inhibitor) 6. Epilepsy or neurological disorders such as Parkinson’s and Alzheimer’s 7. Infectious diseases 8. Those who had taken muscle relaxing drugs such as Benzodiazepines 9. Neuromuscular disorders

Design outcomes

Primary

MeasureTime frame
Changes the level of Total Antioxidants Capacity (TAC) of stimulated and unstimulated saliva. Timepoint: Before intervention and one month after. Method of measurement: Taking 1 ml stimulated and unstimulated saliva samples and measurement of total antioxidant capacity by the ZellBio GmBh (CAT No. ZB-TAC-96A) and (CAT No. ZB-TAC-48A) kits through oxidation-reduction calorimetry.

Secondary

MeasureTime frame
The score of myofascial pain associated with bruxism. Timepoint: Before intervention and one month after. Method of measurement: Numeric Scale Rating (NRS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShamsoulmolouk Najafi

International Campus Branch, Tehran University of Medical Sciences, School of Dentistry

Najafi_sh@tums.ac.ir+98 21 5585 1149

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026