The effect of laser and cream 5 fluorouracil 5% in treatment of vitiligo

Effectiveness comparison of topical 5 fluorouracil and clobetasole combined treatment with/without laser Erbium YAG in vitiligo patients reffering to Isfahan educational clinics

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016090229647N1

Enrollment

Registered

2016-09-17

Start date

2015-11-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitiligo. vitiligo

Interventions

Intervention 1: One of the lesion is randomly treated using one session of Erbium YAG laser( with spot size 2-4 mm and energy 200-500 jouls)until the pinpoint bleeding establishment ( usually 3 pas

Treatment - Devices

Treatment - Drugs

In the other lesion, cream 5 Fluorouracil 5% and cream clobetasole 0.05% are applied once every other day for two months with no laser therapy.

One of the lesion is randomly treated using one session of Erbium YAG laser( with spot size 2-4 mm and energy 200-500 jouls)until the pinpoint bleeding establishment ( usually 3 passes ) . Immediat

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion/exclusion criteria: Inclusion criteria: Age =15 years; patient suffering from vitiligo with at least 2 patch on limbs or trunk( except periungual areas and genitalia); no follicular pigmentation and depigmented hair on lesion Exclusion Criteria: Incidence of drug adverse effects; patients with poor compliance for visit and follow up; pregnancy and lactation; patients with hepatic or hematologic or renal disease; simultaneous application of other therapies .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Vitiligo lesion size change and pigmentation score. Timepoint: 2 months and then 4 months after treatment start. Method of measurement: by pictzar software and pigmentation score for vitiligo by an independent dermatologists blinded to the randomization.	—

Secondary

Measure	Time frame
Pain,burning,Pruritis;atrophy,telangiectasia,acne,scar,swelling, tenderness, infection. Timepoint: Two days, one week , two months and four months after treatment start. Method of measurement: Visit, history and physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAnis Bostakian

Isfahan university of medical science

anisbostakian@gmail.coma.bostakian@resident.mui.ac.ir+98 31 3668 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026