Comparison of the Effects Pre treatment with Acetaminophen and Ibuprofen in Success of Anesthesia in the Lower Jaw with Infected Second Primary Molar Teeth

Comparison of the Effects Pre treatment with Acetaminophen and Ibuprofen in Inferior Alveolar Nerve Block of Second Primary Molar Teeth with Irreversible Pulpitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016083129618N2

Enrollment

Registered

2016-09-05

Start date

2016-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis. Pulpitis

Interventions

Intervention 1: Intervention group 1:1 hour Befor Local anesthesia, used 15 mg/kg of Acetaminophen pretreatment. Intervention 2: Intervention group2:1 hour Before Local anesthesia, used 5 mg/kg of I

Treatment - Drugs

Intervention group 1:1 hour Befor Local anesthesia, used 15 mg/kg of Acetaminophen pretreatment.

Intervention group2:1 hour Before Local anesthesia, used 5 mg/kg of Ibuprofen pretreatment

Control group: 1 hour before Local anesthesia used placebo.

Eligibility

Sex/Gender

All

Age

6 Years to 8 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: children with no history of allergy to Acetaminophen and Ibuprofen; allergy to 2% Lidocaine Anesthetic drugs with 1/200000 epinephrine; no record of intraoral injection; having no unpleasant experience of medical record; phobia from dentistry and no use of analgesic agents during the previous 24 hours periods; mandibular second primary molar with irreversible pulpits without alveolar abscess. Exclusion criteria: systemic diseases; allergy to lidocaine with 1/200000 epinephrine; allergy to anti-inflammatory nonsteroidal drugs peptic ulcer and use of any pain- killer 24 hours before treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain Relief after Local Anestasia Injection. Timepoint: 5 minute after Local Anestasia Injection. Method of measurement: VAS( Visual Analgesic Scale).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Abadi

Department of Pediatric, Dental Faculty of Tabriz University of Medical Sciences

Hamed.abadi@yahoo.com+98 41 3329 4312

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026