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Comparison the effect of intra-articular injection of Bupivacaine and Morphine versus Bupivacaine and Methyl prednisolone on postoperative pain after knee surgery

Comparison the effect of intra-articular injection of Bupivacaine and Morphine versus Bupivacaine and Methyl prednisolone on postoperative pain after knee surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016083125676N5
Enrollment
105
Registered
2017-02-22
Start date
2016-07-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain in knee. Pain in limb

Interventions

Intervention 1: At the end of the surgery in group 1:intra-articular injection of 8 ml bupivacaine 0.5 % with 5 mg morphine will be done. Intervention 2: At the end of the surgery in group 2: int
Prevention
Placebo
At the end of the surgery in group 1:intra-articular injection of 8 ml bupivacaine 0.5 % with 5 mg morphine will be done
At the end of the surgery in group 2: intra-articular injection of 8ml bupivacaine 0.5 % with 40 mg methylprednisolone will be done
At the end of the surgery in group 3: intra-articular injection of 8 ml bupivacaine 0.5 % with 1 ml distilled water will be done

Sponsors

Vice Chancellor for research of Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients 20–80 years old; with American Society of Anesthesiologists (ASA) physical status I or II; scheduled for arthroscopic knee surgery. Exclusion criteria: Patient with neuropathic pain; neurologic deficit in respective organ; surgical history on respective knee; any allergy to used drug; BMI>40; Presence of underlying diseases (cardiac, renal, arthritis & diabetes); chronic pain; coagulopathy; opium addiction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Postoperative pain. Timepoint: 1, 2, 6, 12, 18 and 24 hours after surgery. Method of measurement: Score of pain in Visual analog scale (VAS).;Opioid consumption. Timepoint: During 24 hours after operation. Method of measurement: Mg of Pethidine.

Secondary

MeasureTime frame
Drug side effects. Timepoint: During 24 hrs after the surgery. Method of measurement: Asking the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hoda Shehamat

Qazvin University of Medical Sciences

hoda_shahamat@yahoo.com00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026