Major Depressive Disorder. Depressive episode
Conditions
Interventions
Intervention 1: Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy. and Aspirin (acetyl salysilic acid) 80mg two times per day for 8
Treatment - Drugs
Placebo
Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy + placebo for 8 week
Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy. and Aspirin (acetyl salysilic acid) 80mg two times per day for 8 week that is pr
Sponsors
Vice chancellor for research of Kashan University of Medical Sciences and Health Servisces,Kashan
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with major depressive disorder according to DSM-VI, both gender, and aged between 40 and 80 years old, Consent to participate in the study by completing the informed consent form, Having risk factors for coronary heart disease or stroke. Exclusion criteria: Depression due to physical illness or drug use, A history of gastric ulcers and contraindications for taking aspirin, pregnant women, History of alcohol and substance abuse within 6 months prior to the beginning of the study, positive history of mania, mental retardation, psychosis, using another antidepressant within 4 weeks prior to starting ASA, Candidates for other treatments such as ECT for depression.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: baseline,4 week, and8 week. Method of measurement: Beck Depression Inventory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Fahimi
Kashan University of Medical Sciences and Health Services
Outcome results
None listed