To investigate the post – operative analgesic effect of intra – articular magnesium sulfate / Bupivacaine compared with Tramadol / Bupivacaine after knee arthroscopic surgeries.

To investigate the post – operative analgesic effect of intra – articular magnesium sulfate and Bupivacaine compared with Tramadol and Bupivacaine after knee arthroscopic surgeries.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016082719470N42

Enrollment

Registered

2017-10-01

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

arthrosis of knee. Gonarthrosis [arthrosis of knee]

Interventions

Intervention 1: The first intervention group (T): patients received 100 mg tramadol (50 mg / ml ampoule, Tehran Chemie Pharmaceutical, Tehran, Iran) with 50 mg bupivacaine 0.25% (Bupivacaine-Milan 0.

Treatment - Drugs

The second intervention group (M): patients received 2 g magnesium sulfate (magnesium sulfate 50%, 50 ml vial., Pasteur Institute of Iran, Tehran, Iran) with 0.5 mg bupivacaine (0.25%) as the final v

The first intervention group (T): patients received 100 mg tramadol (50 mg / ml ampoule, Tehran Chemie Pharmaceutical, Tehran, Iran) with 50 mg bupivacaine 0.25% (Bupivacaine-Milan 0.5%, Willy 20 Ml,

Eligibility

Sex/Gender

All

Age

19 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Aged over 19 and under 65 years old; (ASA I-II). Exclusion criteria: Biopsy or simple knee washing; chronic use of opium or tramadol.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: before surgical procedure, in the recovery and 24 hours after surgery. Method of measurement: VAS(visual analog scale).;The morphine IV, PCA pumps and total morphine consumption. Timepoint: 24 hours after surgery at 2, 4, 6, 8, 12, 16, 20, and 24. Method of measurement: Observasion.;Any side effects of analgesics. Timepoint: 24 hours after surgery at 2, 4, 6, 8, 12, 16, 20, and 24. Method of measurement: Observasion.	—

Measure

Time frame

Pain score. Timepoint: before surgical procedure, in the recovery and 24 hours after surgery. Method of measurement: VAS(visual analog scale).;The morphine IV, PCA pumps and total morphine consumption. Timepoint: 24 hours after surgery at 2, 4, 6, 8, 12, 16, 20, and 24. Method of measurement: Observasion.;Any side effects of analgesics. Timepoint: 24 hours after surgery at 2, 4, 6, 8, 12, 16, 20, and 24. Method of measurement: Observasion.

—

Secondary

Measure	Time frame
Patients stisfaction. Timepoint: After surgery in the ward. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfshin Zarei

Shiraz University of Medical Sciences

masihifarzaneh@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026