Bronchopulmonary dysplasia. Bronchopulmonary dysplasia originating in the perinatal period
Conditions
Interventions
Intervention 1: In interventional goup 1 ( early caffeine group ) , the preventive caffeine was started during the first 48 hours of life . At first , Caffeine was administered with a loading dose o
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 30 Days
Inclusion criteria
Inclusion criteria: The preterm neonates with gestational age of 35 weeks or less The preterm neonates with birth weight of 1500 grams or less
Exclusion criteria
Exclusion criteria: The preterm neonates with any underlying condition (e.g. gastrointestinal anomalies, neurological disorders) The preterm neonates with history of receiving any maternal or neonatal relaxant or sedative medications before intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bronchopulmonary dysplasia of preterm neonates. Timepoint: Before intervention and two weeks after the end of intervention (the end of the 36th week of corrected gestational age). Method of measurement: Clinical manifestations and chest-xray findings. | — |
Secondary
| Measure | Time frame |
|---|---|
| Apnea of prematurity. Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: Physical examination.;Need of ventilator therapy. Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: Number of times from questionnaire.;Duration of ventilatilator therapy. Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: As days from questionnaire.;Duration of hospitalization. Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: Number of days from questionnaire.;Intraventricular hemorrhage ( IVH ). Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: Physical examination and brain sonographic findings.;Necrotizing enterocolitis ( NEC ). Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: Physical examination and abdominal x-ray findings.;Patent ductus arteriosus ( PDA ). Timepoint: Before intervention and the end of intervention ( the end of the 36th week of corrected gestational age ). Method of measurement: Physical examination and echocardiographic findings.;Retinopathy of prematurity ( ROP ). Timepoint: Before intervention and the end of the first month of life. Method of measurement: Retinal examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPeymaneh Alizadeh Taheri
Tehran University of Medical Sciences
Outcome results
None listed