The comparison of the efficacy of two therapeutic regimens in the treatment of gastroesophageal reflux disease in term neonates.

The comparison of the efficacy of ranitidine with esoprazole in the recovery rate of signs and symptoms of neonatal gastro esophageal reflux disease ________________________________________

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160827029535N5

Enrollment

Registered

2019-08-21

Start date

2019-09-23

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal Reflux. Gastro-oesophageal reflux disease

Interventions

Intervention 1: Intervention group1: Ranitidine:2mg/kg/dose/TDS. Intervention 2: Intervention group 2: Esomeprazole 0.5mg/kg/dose /BID.

Eligibility

Sex/Gender

All

Age

1 Days to 30 Days

Inclusion criteria

Inclusion criteria: Healthy term neonates aged 1–30days with GERD .

Exclusion criteria

Exclusion criteria: Healthy term neonates aged 1–30days with GERD not responding to conservative therapies including antireflux positioning, milk thickening, hypoallergic regimens and monotherapy

Design outcomes

Primary

Measure	Time frame
The comparison of ranitidine with esomeprazole in neonatal GERD. Timepoint: One week and one month after using each drug. Method of measurement: using (I-GERDQ-R) and related scoring.	—

Secondary

Measure	Time frame
The side effects of each drug. Timepoint: After one week and one month of administering. Method of measurement: Clinical manifestations.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPeymaneh Alizadeh Taheri

Tehran University of Medical Sciences

p.alizadet@yahoo.com+98 73013420

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026