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Effect of atropine vs. ondansetron in preventing nausea and vomiting

Comparison of the effect of atropine and ondansetron in preventing nausea and vomiting during and after caesarean section:A double-blind clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160825029520N4
Enrollment
142
Registered
2023-08-23
Start date
2023-04-21
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention group 1: in this group, 0.5 mg of atropine is injected intravenously by an anesthesiologist (who has no role in data collection) after the complete movement spinal block.

Sponsors

Neyshabour University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age: 18-45 years old Elective surgery Not history of severe nausea and vomiting during pregnancy Complete NPO time Not taking anti-nausea medication before surgery

Exclusion criteria

Exclusion criteria: Heart rate less than 50 or more than 100 during operation History of allergy to the drug that used in this study History of digestive diseases Failed Spinal Anesthesia Bleeding more than 500 cc during surgery Prolonged QT interval

Design outcomes

Primary

MeasureTime frame
Severity of Nausea and Vomiting. Timepoint: Before spinal/ after spinal/ before surgery/ after the umbilical cord clamp/ after surgery/ entering the recovery/ leaving the recovery. Method of measurement: Bellville Nausea and Vomiting scoring scale.

Secondary

MeasureTime frame
Blood pressure. Timepoint: Before spinal/ after spinal/ before surgery/ after the umbilical cord clamp/ after surgery/ entering the recovery/ leaving the recovery. Method of measurement: Anesthesia monitoring.;Heart rate. Timepoint: Before spinal/ after spinal/ before surgery/ after the umbilical cord clamp/ after surgery/ entering the recovery/ leaving the recovery. Method of measurement: Anesthesia monitoring.;Temperature. Timepoint: Before spinal/ after spinal/ before surgery/ after the umbilical cord clamp/ after surgery/ entering the recovery/ leaving the recovery. Method of measurement: Tympanic membrane thermometers.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKiana Babaei

Neyshabour University of Medical Sciences

kianaanesthetist@gmail.com+98 51 4262 7505

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026