Metabolic Syndrom. metabolic disorders not specified
Conditions
Interventions
Intervention 1: Intervention group: 300 g/day probiotic yogurt including Lactobacillus acidophilus La5 and bifidobacterium lactis Bb12 for 8 weeks. Intervention 2: Placebo group: 300 g/day regular yog
Prevention
Placebo
Intervention group: 300 g/day probiotic yogurt including Lactobacillus acidophilus La5 and bifidobacterium lactis Bb12 for 8 weeks
Placebo group: 300 g/day regular yogurt
Sponsors
Vice chancellor for research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Willingness to participate; women and men aged 20-65 years; diagnosis of the metabolic syndrome based on the presence of any 3 of the criteria defined by the Iranian National Committee of Obesity: waist circumference =95 cm in both genders; fasting serum glucose =100 mg/dl; serum triglyceride =150 mg/dl; serum HDL cholesterol <40 mg/dl in men and <50 mg/dl in women; systolic blood pressure =130 mmHg and/or diastolic blood pressure =85 mmHg. Exclusion criteria: suffering from cardiovascular disease, renal failure, diabetes and gastrointestinal diseases; receiving antibiotics; supplement of vitamin and minerals, fiber, omega-3 and probiotic supplements during the two months before the start of the study; presence of pregnancy or lactation or menopause; extreme sports more than 100 minutes per week; having the weight loss diet the three months before the study; hormone therapy; taking contraceptive drugs; alcohol intake, smoking and tobacco; history of cancer and medical treatment and drugs that affect the neuroendocrine function, metabolism or appetite; thyroid problems; gastrointestinal surgery during the past year; treatment with immunomodulatory drugs one month before the study; chronic use of laxative (more than twice a week).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose. Timepoint: Begining and end of the intervention. Method of measurement: Enzymatic.;Insulin, insulin resistance index. Timepoint: Begining and end of the intervention. Method of measurement: ELISA and HOMA-IR formula.;Lipid profile. Timepoint: Begining and end of the intervention. Method of measurement: Spectrophotometry.;Blood pressure. Timepoint: Begining and end of the intervention. Method of measurement: Digital monometer.;Anthropometry markers. Timepoint: Begining and end of the intervention. Method of measurement: Stadiometer, scale, tape.;Tumor Necrosis Factor-Alpha (TNF-a). Timepoint: Begining and end of the intervention. Method of measurement: ELISA.;Interleukin-6 (IL-6). Timepoint: Begining and end of the intervention. Method of measurement: ELISA.;Hs-CRP. Timepoint: Begining and end of the intervention. Method of measurement: Immunotorbidometry.;Lipopolysaccharides (LPS). Timepoint: Begining and end of the intervention. Method of measurement: ELISA.;Malondialdehyde (MDA). Timepoint: Begining and end of the intervention. Method of measurement: Spectrophotometry.;Total Antioxidant Capacity. Timepoint: Begining and end of the intervention. Method of measurement: Spectrophotometry.;Uric Acid. Timepoint: Begining and end of the intervention. Method of measurement: Enzymatic.;Oxidized LDL (OxLDL). Timepoint: Begining and end of the intervention. Method of measurement: ELISA.;Plasminogen Activator Inhibitor-1 (PAI-1). Timepoint: Begining and end of the intervention. Method of measurement: ELISA.;Vascular Cell Adhesion Molecule Type 1 (VCAM-1). Timepoint: Begining and end of the intervention. Method of measurement: ELISA.;Intercellular Adhesion Molecule Type 1 (ICAM-1). Timepoint: Begining and end of the intervention. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Appetite. Timepoint: Begining and end of the intervention. Method of measurement: Appetite Questionnaire (Visual Analouge Scale).;Physical activity. Timepoint: Begining and end of the intervention. Method of measurement: International Physical Activity Questionnaire.;Energy and macronutrients intake. Timepoint: Begining and end of the intervention. Method of measurement: Three day dietary record questionnair. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeila Rezazadeh
Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences
Outcome results
None listed