Effect of Topical Oil Melilotus officinalis on primary knee Osteoarthritis versus Diclofenac gel

Assessment of Topical Oil Melilotus officinalis effect on clinical sings of primary knee Osteoarthritis versus Diclofenac gel : A double blind study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016082129461N1

Enrollment

Registered

2017-01-09

Start date

2017-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary osteoarthrit. Primary generalized (osteo)arthrosis M15.0

Interventions

Intervention 1: 5 drops Oil Melilotus officinalis in the front knee In the morning and evening. Intervention 2: 5Drop of Diclofenac gel in front of knee In the morning and evening.

Treatment - Drugs

Placebo

5 drops Oil Melilotus officinalis in the front knee In the morning and evening

5Drop of Diclofenac gel in front of knee In the morning and evening

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: 60 years old and older ?pain at least in one knee over the last 3 months? Weak to moderate osteoarthritis (grade 1 to 3 based on criteria) Kellegren-Lawrence (K-L) grading scale? The existence of moderate pain, with minimum galling, according to VAS, at least for four weeks before entering the random assignment Exclusion criteria: Sensitivity, and allergies, to Melilotus officinalis vegetable oil and Diclofenac gel? Skin lesion in the knee area? Secondary osteoarthritis in the rheumatic diseases such as rheumatoid arthritis, gout, septic arthritis, metabolic arthritis, traumatic arthritis? Patients who had joint replacement with surgery ? Using from oral and local, steroids, within 14 days before study? Injecting the, intra-articular steroid within 90 days before study? Alcoholism, and addiction to drugs? Having radiculopathy and neuropathy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Improve of Physical Activity. Timepoint: in beginning of intervention; 2 and 4 week after beginningintervention. Method of measurement: questionnaire.	—

Secondary

Measure	Time frame
Decrease of pain. Timepoint: beginning of intervention; 2 and 4 week after beginningin tervention. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholam Reza Ansari

Kodakyar deadlock Boulevard student Evin field . Welfare and Rehabilitation Sciences University / Ce

gh.ansari@uswr.ac.ir+98 21 2218 0154

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 22, 2026