The effect of melatonin on the eradication of Helicobacter pylori

Effect of melatonin addition to quadruple therapy (Bismuth, Amoxicillin, Metronidazole, Proton pump inhibitors) for the eradication of Helicobacter pylori (H.pylori) in people who have proven H.pylori infection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016082111192N5

Enrollment

Registered

2017-04-08

Start date

2016-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori. Disease of stomach and duodenum, unspecified

Interventions

Intervention 1: Intervention 1: Addition of melatonin tablet orally 3 mg/d to eradication regimen of Helicobacter pylori for 2 weeks. Intervention 2: Intervention 2:Addition of melatonin placebo 1 tab

Treatment - Drugs

Intervention 1: Addition of melatonin tablet orally 3 mg/d to eradication regimen of Helicobacter pylori for 2 weeks

Intervention 2:Addition of melatonin placebo 1 tablet per day orally to eradication regimen of Helicobacter pylori for 2 weeks

Eligibility

Sex/Gender

All

Age

15 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients in need of eradication of Helicobacter pylori ( H.pylori) in Taleghani Hospital by obtaining personal wright Exclusion criteria: People who have proven that H. pylori infection but not require treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Eradication of Helicobacter pylori. Timepoint: 1month after finishing drugs. Method of measurement: Assessing the stool antigen test.	—

Secondary

Measure	Time frame
Side effects of the treatment regimen. Timepoint: 1 month after finishing drugs. Method of measurement: asking patients.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNima Naderi

Deputy of research, School of Pharmacy, Shahid Beheshty Universiti of Medical Sciences

naderi@sbmu.ac.ir00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026