patients on maintenance-hemodialysis who are undergoing cadaveric kidney transplantation. Kidney transplant status
Conditions
Interventions
Intervention 1: In intervention group 600 mg acetylcysteine is administered one dose before transplantation and then twice per day from day one to five after transplantation. Intervention 2: In contro
Prevention
In intervention group 600 mg acetylcysteine is administered one dose before transplantation and then twice per day from day one to five after transplantation.
In control group placebo is administered one dose before transplantation and then twice per day from day one to five after transplantation.
Sponsors
Vice chancellor for research, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: "Patients on maintenance dialysis who are undergoing cadaveric renal transplantation" Exclusion criteria: "preemptive kidney transplantation (transplantation prior to initiation of dialysis), multi-organ transplants, second transplantation, history of using NAC within the month prior to operation, and history of sensitivity to sulfa drugs"
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glutathione peroxidase activity in erythrocytes and serum malondialdehyde levels. Timepoint: pre-transplantation and 5 days after transplantation. Method of measurement: Randox Laboratories commercial kits for Glutathione peroxidase and biochemical method for malondialdehyde. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: daily. Method of measurement: biochemical method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtieh Modarresi
school of pharmacy
Outcome results
None listed