Acute postoperative pain. R52.0 Acute Pain
Conditions
Interventions
Intervention 1: The study group ( n=33) receive bolus dose of magnesium sulfate 1g into 100ml normal saline over 15 min and bolus ketamine 15 mg over 2-3 min prior to induction of anesthesia. Then mag
Prevention
The study group ( n=33) receive bolus dose of magnesium sulfate 1g into 100ml normal saline over 15 min and bolus ketamine 15 mg over 2-3 min prior to induction of anesthesia. Then magnesium sulfate 1
In the placebo group: normal saline 100ml during 15 min before the surgery and 300 ml during surgery are infused.
Sponsors
Vice chancellor for reaserch, Tabriz University of Medical Scienses
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Inclusion criteria: Scheduled for elective abdominal hysterectomy; ASA class I, II. Exclusion criteria: Emergence hysterectomy; history of systemic diseases (renal, cardiovascular; respiratory, hepatic, neuromuscular and ...); history of psychopathy; BMI>35; calcium Chanel inhibitor consumption; recent magnesium therapy; history of chronic pain syndrome; pregnancy; history of alcohol and opioid consumption
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: PACU and at 1, 3, 6, 12 and 24h after surgery. Method of measurement: visual analogue scale(VAS) (0= non to 10= severe pain) cm). | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall dose of postoperative analgesic. Timepoint: PACU and during 24h postoperatively. Method of measurement: number and amount of medication by mg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Simin Atashkhoei
Vice chancellor for research, Tabriz University of Medical? Sciences
Outcome results
None listed