Investigating the effect of exosome derived from menstrual blood mesenchyme cells on infertility in PCOS patiens

Investigating the effect of ovarian exosome injection derived from allograft menstrual blood mesenchyme cells on infertility in PCOS patiens

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160815029374N9

Enrollment

Registered

2025-03-15

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Investigating the effect of ovarian rexosome injection derived from allograft menstrual blood mesenchyme cells on infertility in pcos patiens. IV Endocrine, nutritional and metabolic diseases

Interventions

Intervention 1: Intervention group: 11 PCOS patients undergoing intraovarian injection of exosome in the follicular phase. Intervention 2: Control group: 11 PCOS patients without intraovarian injectio

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: PCOS patients Normal Sperm analysis Age 20 to 40 years BMI=28-32, BMI <28 Kg/m2 Normal uterine on hysterosalpingography or sonography History of unsuccessful IVF

Exclusion criteria

Exclusion criteria: Active infection Active cancer Chronic multi-organ failure Diabetes Pregnancy Previous member link Patients with positive diagnosis of hepatitis A, B, C and HIV Abnormal uterine shape on hysterosalpingography or hysteroscopy Blood or immunological diseases Chromosomal and genetic abnormalities (acquired or congenital) Successful pregnancy history Cushing's syndrome Uncontrolled thyroid dysfunction (hypothyroidism and hyperthyroidism)

Design outcomes

Primary

Measure	Time frame
Egg (Oocyte) number. Timepoint: Before injection and two months after injection. Method of measurement: Number of egg formed in the IVF cycle before injection and two months later.;Egg (Oocyte) quality. Timepoint: Before injection and two months after injection. Method of measurement: Based on embryological criteria (metaphase 1 and 2 and germinal vesicle).;Embryo number. Timepoint: Before injection and two months after injection. Method of measurement: Number of embryos formed in the IVF cycle before injection and two months later.;Embryo quality. Timepoint: Before injection and two months after injection. Method of measurement: Grade A, B, C, D based on embryological criteria.	—

Measure

Time frame

Egg (Oocyte) number. Timepoint: Before injection and two months after injection. Method of measurement: Number of egg formed in the IVF cycle before injection and two months later.;Egg (Oocyte) quality. Timepoint: Before injection and two months after injection. Method of measurement: Based on embryological criteria (metaphase 1 and 2 and germinal vesicle).;Embryo number. Timepoint: Before injection and two months after injection. Method of measurement: Number of embryos formed in the IVF cycle before injection and two months later.;Embryo quality. Timepoint: Before injection and two months after injection. Method of measurement: Grade A, B, C, D based on embryological criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactkataneh kazemi

Mazandaran University of Medical Sciences

kazemi.kataneh61@gmail.com+98 915 325 4575

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026