Effects of letrozole in combination with clomiphene on infertility

Comparison of the effects of letrozole with letrozole in combination with clomiphene on ovulation and pregnancy rate in infertile patients with polycystic ovarian syndrom under Ovulation induction

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160815029374N6

Enrollment

194

Registered

2019-05-24

Start date

2019-04-04

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disease of genitourinary tract. Female infertility

Interventions

Intervention 1: Intervention group 1: Letrozole (2.5 mg tablet, Iranian hormones Company) is given twice daily from the third to seventh day of the menstrual cycle. Intervention 2: Intervention group

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Female aged 35 or lower Mild male factor infertility Poly cyctic ovarian syndrome

Exclusion criteria

Exclusion criteria: Reluctance to participate in study Body mass index above 27 Endocrine disorder including Hypothyroidism, hyperprolactinemia Diminished ovarian reserve History of pelvic surgery History of ovarian hyperstimulation syndrome Severe male factor infertility Abnormal hysterosalpingography

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate. Timepoint: Three weeks after positive B-HCG. Method of measurement: ultrasonography.;Ovulation rate. Timepoint: Forty-eight hours after HCG injection. Method of measurement: ultrasonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Zamanian

Mazandaran University of Medical Sciences

m.zamanian@mazums.ac.ir+98 11 3336 5724

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026