Diseases of the genitourinary system. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: Intrauterine infusion of 0.5 CC of autologus platelet-rich plasma (has 4-6 times platelet concentration rather than peripheral blood by IUI catheter(Takvin company
Treatment - Other
Intervention group: Intrauterine infusion of 0.5 CC of autologus platelet-rich plasma (has 4-6 times platelet concentration rather than peripheral blood by IUI catheter(Takvin company, Iran) 48 hours
Control group: Transfer of three Freeze embryos by chateter ( Cook, USA) under ultrasonographic guidance.
Sponsors
Vice chancellor of Mazandaran University of Medical Science.
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women aged 20-40 year Body mass index lower than 30 Kilogram per square meter Normal husterosalpingography At least prior three failed in vitro fertilization failure
Exclusion criteria
Exclusion criteria: Hematologic disorders (blood cancer, thrombocytopenia) Immunologic disorders (anti-phospholipid syndrome, thrombophilia) Hormonal disorders (diabetes, thyroid, hyperprolactinemia) Chromosomal anomalies and genetics (herditary or congenital) Renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate. Timepoint: Forth weeks after embryo transfer. Method of measurement: Questionnare. | — |
Secondary
| Measure | Time frame |
|---|---|
| Miscarriage rates. Timepoint: Till twenty weeks after embryo transfer. Method of measurement: Questionnare.;Implantation rate. Timepoint: Forth weeks after embryo transfer. Method of measurement: Questionare. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Zamaniyan
Mazandaran University of Medical Sciences
Outcome results
None listed