Infertility. Female infertility associated with anovulation
Conditions
Interventions
Intervention 1: Intervention group: From these patients, 20 milliliters of peripheral blood will be drawn and placed into tubes containing the anticoagulant EDTA. After isolating PBMCs using Ficoll, t
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Minimum history of 3 previous unsuccessful IVF/ET treatments Primary infertility cases Age under 40 years BMI between 18 and 25 Regular and natural menstrual cycles for at least 3 consecutive months (each cycle lasting between 25-35 days) Failure to identify specific primary causes in the development of infertility conditions
Exclusion criteria
Exclusion criteria: Abnormal levels of thyroid hormones / FSH / LH / Estrogen / Progesterone / GH / Insulin / Glucagon Presence of anatomical problems in the uterus using ultrasound or hysteroscopy Presence of a history of genetic disease or an abnormal karyotype in the mother or father, or through cytological examinations. Presence of coagulation disorder and abnormal thrombophilia screening (V Leiden, Prothrombin, Antithrombin III) Evidence of genital infection The presence of a specific cause or related underlying factor associated with pregnancy failure Presence of a tumor or other diseases with abnormal test results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Clinical pregnancy onset). Timepoint: Two weeks. Method of measurement: Test and ultrasound.;(Implantation rate). Timepoint: Two weeks. Method of measurement: Test and ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| The extent of side effects resulting from the treatment will also be evaluated based on the designed questionnaire and the specialist doctor's visit. Timepoint: two week. Method of measurement: exam - Ultrasound.;The relationship between the incidence of clinical pregnancy in patients with recurrent implantation failure (RIF) and the Th1/Th2 cell ratio will be determined. Timepoint: two week. Method of measurement: exam - Ultrasound.;The impact of endometrial thickness at the time of embryo transfer on treatment effectiveness will be evaluated in the intervention group. Timepoint: two week. Method of measurement: exam - Ultrasound.;The impact of the number of previous failures (the number of unsuccessful IVF attempts) on the effectiveness of treatment with hCG-treated PBMCs will be evaluated. Timepoint: two week. Method of measurement: exam - Ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Zamaniyan
Mazandaran University of Medical Sciences
Outcome results
None listed