Effect of botulinum toxin and Sphincterotomy in treatment of anal fissure

Comparative outcomes of botulinum toxin and Sphincterotomy in treatment of chronic anal fissure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016081429352N1

Enrollment

Registered

2016-09-10

Start date

2016-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic anal fissure. Chronic anal fissure

Interventions

Intervention 1: Botulinum toxin 25 unit, injection, single dose. Intervention 2: Sphincterotomy.

Treatment - Drugs

Treatment - Surgery

Botulinum toxin 25 unit, injection, single dose

Sphincterotomy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: history of chronic anal fissure; skin tag or visible fibers of internal muscles of anal on bottom of ulcer exclusion criteria: acute anal fissure; fistula; inflammatory bowel disease; history of anal surgery; pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Wound healing. Timepoint: 1,2,4,8 and then monthly for 6 month after treatment. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Pain During Defecation. Timepoint: 1,2,4,8 and then monthly for 6 month after treatment. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Gharib

Islamic Azad University of Shahroud

ehsangharib90@yahoo.com+98 23 3239 0077

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026