The effect of Dexmedetomidine and Labetalol on changes in heart rate and blood pressure after laryngoscopy and intubation and comparison with control group

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160812029310N3

Enrollment

120

Registered

2018-05-09

Start date

2018-05-10

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Heart rate changes. Condition 2: Systolic blood pressure changes. Condition 3: Diastolic blood pressure changes. Condition 4: mean atrial pressure.

Interventions

Intervention 1: Intervention group A: First, informed consent is obtained from the patients. After placement of patients on the operating bed, after the inclusion of standard monitoring including puls

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients undergoing elective surgery in Al-Zahra Hospital, aged between 18 and 60, under general anesthesia, are physically inactive except for ASA I and II, as well as alcohol and drug addiction.

Exclusion criteria

Exclusion criteria: A history of allergy Block grade 3 Asthma Heart failure History of myocardial infarction in the last six months Ischemic Heart Disease Taking TCA Taking MAOI Fever Obesity (BMI greater than 27) Neurological diseases respiratory diseases

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Pulse oximetry device.;Median arterial blood pressure. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Mercury pressure gauge device.;Systolic blood pressure. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Mercury pressure gauge device.;Diastolic blood pressure. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Mercury pressure gauge device.	—

Measure

Time frame

Heart rate. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Pulse oximetry device.;Median arterial blood pressure. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Mercury pressure gauge device.;Systolic blood pressure. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Mercury pressure gauge device.;Diastolic blood pressure. Timepoint: Before the intervention, and then after the intervention, one, three, five, ten minutes after the intubation and then at 60 and 120 minutes after induction of anesthesia. Method of measurement: Mercury pressure gauge device.

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Secondary

Measure	Time frame
Duration of stay in recovery. Timepoint: From logging in to recovery until recovery is released. Method of measurement: Minutes.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArsham Kamali

Esfahan University of Medical Sciences

arshamkamali1992@gmail.com+98 77 3353 6409

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026