vitamin c in diabetes

Evaluation of effects of vitamin C supplementation on LCAT (lecithin-cholesterol Acyltransferas) activity compared to plcebo in patients with type 2 diabetes

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160811029306N2

Enrollment

Registered

2020-11-11

Start date

2020-11-05

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: Oral vitamin c supplement. Intervention 2: Control group: Placebo.

Eligibility

Sex/Gender

All

Age

30 Years to 75 Years

Inclusion criteria

Inclusion criteria: Type2 diabetes More than 2 years history of type2 diabetes

Exclusion criteria

Exclusion criteria: pregnancy vitamin supplementation glucocorticoid use renal failure history of heart failure smoking liver failure malignancy acute inflammation and infection antioxidant drugs allergy to vitamin c hypothyroidism renal stone

Design outcomes

Primary

Measure	Time frame
LCAT( lecithin-cholestrol Acyltransferas). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: LCAT will be measured by spectrophotometric assay.;HbA1c. Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: Hb A1C will be measured by electrophoresis.;High Density Cholesterol (HDL). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: HDL will be measured by Direct Enzymatic.;Low Density Cholesterol (LDL). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: LDL will be measured by Direct Enzymatic.;Insulin. Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: Insulin will be measured by Chemiluminescence immunoassay.;Triglyceride (TG). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: TG will be measured by enzymatic (GPO-POD) method.;Fasting Blood Glucose (FBS). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: FBS will be measured by enzymatic (GOD) method.;Creatinine (Cr). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: Cr will be measured by photomrtric method.(PICRATE/KINETC).;Aspartate transaminase (AST). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: AST will be measured by enzymatic method.;Alanine transaminase (ALT). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: ALT will be measured by enzymatic method.	—

Measure

Time frame

LCAT( lecithin-cholestrol Acyltransferas). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: LCAT will be measured by spectrophotometric assay.;HbA1c. Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: Hb A1C will be measured by electrophoresis.;High Density Cholesterol (HDL). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: HDL will be measured by Direct Enzymatic.;Low Density Cholesterol (LDL). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: LDL will be measured by Direct Enzymatic.;Insulin. Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: Insulin will be measured by Chemiluminescence immunoassay.;Triglyceride (TG). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: TG will be measured by enzymatic (GPO-POD) method.;Fasting Blood Glucose (FBS). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: FBS will be measured by enzymatic (GOD) method.;Creatinine (Cr). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: Cr will be measured by photomrtric method.(PICRATE/KINETC).;Aspartate transaminase (AST). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: AST will be measured by enzymatic method.;Alanine transaminase (ALT). Timepoint: Blood sample will be taken before and 2 months after treatment with vitamin c . Method of measurement: ALT will be measured by enzymatic method.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactmanouchehr nakhjavani

Tehran University of Medical Sciences

nakhjavanim@tums.ac.ir+98 21 61190

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026