Comparison of labetalol and dexmedetomidin on bleeding during endoscopic sinus surgery

Comparison of labetalol and dexmedetomidine on reducing blood pressure and bleeding during endoscopic sinus surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016080914056N8

Enrollment

100

Registered

2016-09-15

Start date

2016-01-18

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic sinusitis. Chronic sinusitis

Interventions

Intervention 1: Dexmedetomidine at dose of 1 µg/kg injected over 10 minutes then 0.4 to 0.8 µg/kg/h IV infused. Intervention 2: Labetalol at dose of 0.25 mg/kg injected over 10 minutes then 1 to1 mg/

Prevention

Dexmedetomidine at dose of 1 µg/kg injected over 10 minutes then 0.4 to 0.8 µg/kg/h IV infused.

Labetalol at dose of 0.25 mg/kg injected over 10 minutes then 1 to1 mg/min IV infused.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA class I and II; Age between 18 to 60 years old; Patients satisfaction. Exclusion criteria: pregnancy; history of cardiovascular diseases (Arrhythmia, ischemia, and heart block); history of coagulopathies; taking opioids; History of sensitivity to the drugs used in this study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Bleeding volume. Timepoint: End of surgery. Method of measurement: Suctioned blood volume.;Mean arterial pressure. Timepoint: Every 10 minutes till the end of surgery. Method of measurement: In mmHg with intra arterial manometry.;O2 saturation. Timepoint: Every 10 minutes till the end of surgery. Method of measurement: Pulse oxymeter.;Heart rate. Timepoint: Every 10 minutes till the end of surgery. Method of measurement: With cardiac monitoring.	—

Measure

Time frame

Bleeding volume. Timepoint: End of surgery. Method of measurement: Suctioned blood volume.;Mean arterial pressure. Timepoint: Every 10 minutes till the end of surgery. Method of measurement: In mmHg with intra arterial manometry.;O2 saturation. Timepoint: Every 10 minutes till the end of surgery. Method of measurement: Pulse oxymeter.;Heart rate. Timepoint: Every 10 minutes till the end of surgery. Method of measurement: With cardiac monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesameddin Modir

Arak University of Medical Sciences

He_modir@yahoo.com+98 86 3417 3641

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026