Blood Loss after Total Knee Arthroplasty. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: 15 mg/kg TXA intra-Articular injection post-operative. Intervention 2: Control group: 5 mg/kg TXA intravenous injection.
Sponsors
Joint Reconstruction Research Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Total knee arthroplasty candidate patients Surgery in Imam Khomeini Hospital Not having a specific bleeding disorder Not having any co-morbidity Not having any cardiovascular diseases Accept the terms of participation in the study voluntarily
Exclusion criteria
Exclusion criteria: Cardiovascular diseases Any co-morbidity Any bleeding disorders Thromboembolie and stroke history Not voluntary Sensitivity to tranexamic acid Revision TKA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative Hb to pre-operative Hb. Timepoint: Pre-operative, 24 hour post-operative, 48 hour post-operative, 72 hour post-operative. Method of measurement: With blood lab test and blood loss calculation with GOOD & NADLER formulae. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of vascular thrombosis, DVT, Stroke and embolism. Timepoint: At least two years Follow-up. Method of measurement: Physical exam and para-clinics. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Moharrami
Tehran University of Medical Sciences
Outcome results
None listed