Breast Cancer. Malignant neoplasm of breast
Conditions
Interventions
Intervention 1: Intervention group1: 5 patients receiving IL-2-stimulated autologous NK cells. 60 cc of peripheral blood is taken from the patients and cultured after isolation of NK cells, these cell
Sponsors
Knowledge-based company of Pooya Gostar royana Iranian
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Women between 20 and 50 years of age with clinically proven breast cancer by the relevant oncologist. Less than 5 times (or 5 times) the level of liver enzymes ALT, AST, and total bilirubin above the upper limit of the relevant normal range. Have a creatinine level of less than 2.0 mg/dL Failure to respond to other conventional treatments (chemotherapy, etc.) The patient's expected survival time is at least 3 months. Filling out the informed consent form
Exclusion criteria
Exclusion criteria: Having any serious underlying disease other than breast cancer (HIV, HBS, HCV, HTLV1, myocardial infarction in the last 3 months, ...) Drug or alcohol use Having concurrent autoimmune diseases or having a history of acute hypersensitivity Pregnancy or breastfeeding Evidence of cancer metastasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: monthly. Method of measurement: Outcome No. 1: Doctor's face-to-face meeting with the patient and examination of clinical signs, CT scan, and histopathological examinations.;Outcome No. 2: Sensitivity Assessment. Timepoint: Days 1 and 7 and 30 after intervention. Method of measurement: Patient visit and evaluation of fever, chills, headache and inflammatory cytokines.;Outcome No. 3: Tumor size change. Timepoint: Monthly. Method of measurement: Physical exam and CT scan. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Jalil Tavakkol Afshari
Mashhad University of Medical Sciences
Outcome results
None listed