Covid-19 disease. Severe Acute Respiratory Syndrome coronavirus
Conditions
Interventions
Intervention 1: Intervention group: Group receiving mesenchymal stem cells. In this group, patients in 3 times (1, 3 and 6 days) are received 1 million Umbilical core-derived MSCc/BW by intravenous in
Sponsors
Mashhad University of Medical Sciences
Parnia stem cell Knowledge-based company
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Covid-19 patient with acute respirstory infectious symptoms and severe lung involvement Pulmonary compliance more than 40 Age category 18-70 years PI02/FIo2 between 100 - 300
Exclusion criteria
Exclusion criteria: Covid-19 patient with Sepsis Pregnancy The presence of malignancy or other underlying diseases Patient with age conditions outside the range of 18-70 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory symptoms and pulmonary function in patients. Timepoint: In onset of study and days 2, 7 and 14 after the second injection. Method of measurement: Using CT scan image , physical examination , Oxygen saturation Percentage.;Evaluation of IFN-?,IL4,TGF-ß,IL1-ß , IL-6 and TNF-a cytokine levels in patients blood. Timepoint: In onset of study and days 2, 7 and 14 after the second injection. Method of measurement: Using Elisa kits.;Cell markers and populations. Timepoint: In onset of study and days 2, 7 and 14 after the second injection. Method of measurement: Using Flow cytometery technique. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyad Jalil Tavakol Afshari
Mashhad University of Medical Sciences
Outcome results
None listed