The Effect of remifentanil on Mini-mental status examination after electroconvulsive therapy in major depressive patients.

Evaluation of the incidence and severity of cognitive impairment after electroconvulsive therapy under general anesthesia with remifentanil in patients referred to electroconvulsive therapy shaft center , Rasht in 1395

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201608086280N10

Enrollment

Registered

2016-10-02

Start date

2016-09-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Patients With Major Depressive Disease. Severe depressive episode with psychotic symptoms

Interventions

Intervention 1: In intervention group , the patients will receive remifentanil as the sole agent anesthetic with doses : 4-8 µg/kg ,and the suuccynilcholine will administerd for relaxation.Th

Treatment - Drugs

In intervention group , the patients will receive remifentanil as the sole agent anesthetic with doses : 4-8 µg/kg ,and the suuccynilcholine will administerd for relaxation.The patients will

In control group the patients will receive thiopental 4 mg/kg with equal volume of that prepare by normal saline. The patients will ventilated by bag and mask with 100% of oxygen till the bi-tempo

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 60 patients between 18-60y; major depression; meet the DSM-TR IV ;. elective electroconvulsive therapy will performed only in 1th. The exclusion criteria : the patients with ASA class IV ; mild to moderate cognitive disorder; emergency condition; history of cardiovascular disease; mental retardation ; uncontrolled hypertension.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cognitive Disorder after ECT. Timepoint: Before the ElectroConvulsive Therapy and 5 and 24 hours after ECT procedure. Method of measurement: MMSE Questionnaire 24-30, no cognitive problem 23-18mild cognitive problem 0-17,sever cognitive problem.	—

Secondary

Measure	Time frame
Heart Rate. Timepoint: before electro convulsive therapy /5 and 24 hour after ECT. Method of measurement: ECG.;Blood Presssure. Timepoint: the time before electro convulsive therapy /5 and 24 hour after ECT. Method of measurement: NonInvasive Blood Pressure .;Seizure Duration . Timepoint: before electro convulsive therapy /5 and 24 hour after ECT. Method of measurement: By chronometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDrMohammad Haghighi

Anesthesiology Research Center, Guilan University Of Medical Sciences

MANESTHESIST@GMAIL.COM+98 13133323970

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026