Evaluation of the efficacy of memantine in children with attention deficit hyperactivity disorder

A Comparison of the Effect of Memantine added to Ritalin and Ritalin alone on cognitive Functions (Selective Attention, Sustained Attention, and Reverse Shot-term Memory) of Children with Attention Deficit and Hyperactivity Disorder (ADHD): A Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016080829268N1

Enrollment

Registered

2017-06-11

Start date

2016-04-25

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention deficit hyperactivity disorder. mental and behavioural disorders

Interventions

Intervention 1: Intervention Group: The research variables including severity of disorder, sustained attention, selective attention and reverse short-term memory were measured using Conners’ teacher a

Treatment - Drugs

Intervention Group: The research variables including severity of disorder, sustained attention, selective attention and reverse short-term memory were measured using Conners’ teacher and parent rating

Control Group: After obtaining informed consents from parents, The research variables including severity of disorder, sustained attention, selective attention and reverse short-term memory were measur

Eligibility

Sex/Gender

All

Age

7 Years to 12 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: The presence of hyperactivity disorder for both groups in children aged between 7-12 years old according to Statistical Manual of Mental Disorders, Fourth Edition (DSMIV). Exclusion Criteria: The presence of neurological disorders; mental retardation disorders; disorders causing a decreased level of consciousness at the testing time; autism disorder; bipolar disorders; psychosis; depression and anxiety in terms of interviews with pediatric psychiatrist as well as drug side effects which led to drug intolerance.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Symptoms of hyperactivity and impulsivity. Timepoint: Before and one mounth after intervention. Method of measurement: Conners questionnaire for parents and teachers.;Sustained attention. Timepoint: Continuous Performance Test (CPT). Method of measurement: Before and one mounth after intervention.;Selective attention. Timepoint: stroop test. Method of measurement: Before and one mounth after intervention.;Reverse short-term memory. Timepoint: Wechsler Digit Span Test. Method of measurement: Before and one mounth after intervention.	—

Measure

Time frame

Symptoms of hyperactivity and impulsivity. Timepoint: Before and one mounth after intervention. Method of measurement: Conners questionnaire for parents and teachers.;Sustained attention. Timepoint: Continuous Performance Test (CPT). Method of measurement: Before and one mounth after intervention.;Selective attention. Timepoint: stroop test. Method of measurement: Before and one mounth after intervention.;Reverse short-term memory. Timepoint: Wechsler Digit Span Test. Method of measurement: Before and one mounth after intervention.

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Secondary

Measure	Time frame
Adverse effect of Memantine. Timepoint: During the intervention and one month after intervention. Method of measurement: Observation and parents' narration.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Omidi Fahimeh

Arak University of Medical Sciences

f.omidi@arakmu.ac.ir+98 33 1360 5558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026