Effect of three Isoflurane, Sevoflurane, and Propofol+ Remifentanil drugs in terms of hemodynamic status, and also bleeding in lumbar spine surgery

Compare among the three Isoflurane, Sevoflurane, and Propofol+ Remifentanil drugs in terms of hemodynamic status, and also bleeding in controlled hypotension, during lumbar spine surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016080829261N1

Enrollment

Registered

2017-03-08

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Controlled Hypotention. Hypotension due to drugs

Interventions

Intervention 1: Drugs: 1-Propofol: Dose: 100-200 µg/kg/min Route of administration: Infusion Factory name: Dongkook Pharma Manufacturing Country's Name: Korea Location prescribed: Intravenous Admin

Treatment - Drugs

Drugs: 1-Propofol: Dose: 100-200 µg/kg/min Route of administration: Infusion Factory name: Dongkook Pharma Manufacturing Country's Name: Korea Location prescribed: Intravenous Administration

Isoflurane: Dose: 1-2% Mean Alveolar Concentration Route of administration: Inhalation Factory name: Piramal Manufacturing Country's Name: India Administration time: During surgery

Sevoflurane: Dose: 1-2% Mean Alveolar Concentration Route of administration: Inhalation Factory name: Piramal Manufacturing Country's Name: India Administration time: During surgery

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria are: Spinal surgery to the aim of laminectomy, age between 18 to 65 years old; and ASA= II. The exclusion criteria are: patient’s lack of consent; having allergy to Propofol, soya, egg or Isoflurane; history of malignant hyperthermia in the patient and his/her family; patients with history of coagulopathy or consumption of coagulation-related drugs; any history of any diseases such as stroke, coronary artery diseases, hypertension, deep veins thrombosis, pulmonary embolism, and peripheral vascular diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: During Surgery. Method of measurement: Milliliter.	—

Secondary

Measure	Time frame
Mean Arterial Pressure. Timepoint: Before and after induction, after change of position, 30, 60 and 90 minutes after start of the operation, and at the end of operation. Method of measurement: Milimeter Hg.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHoma Hamdan

Ahvaz Jundishapur University of Medical Sciences

hamdan.h@ajums.ac.ir; mostafafatahi777@gmail.com+98 61 1435 1247

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026