neoplasm. Malignant Neoplasm of Temporal Lobe
Conditions
Interventions
Generation of immature dendritic cells from isolated monocytes of patients, pulsing of DCs with autologous tumor lysate, induction of maturation in DCs, reinfusion of mature DCs to patient
This study
Treatment - Other
Generation of immature dendritic cells from isolated monocytes of patients, pulsing of DCs with autologous tumor lysate, induction of maturation in DCs, reinfusion of mature DCs to patient
This study
Sponsors
Urmia University of Medical Science
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Brain tumor without metastases or recurrence; glioma; meduloblastoma; CD4>350 cell/mm; 3-18 months = age =15 years; 10Kg =Weight; Confirmation of informed consent; Normal serum tests; Immunotherapy should be started at least 3 wks after last chemo or radiotherapy course Exclusion criteria: Cardiovascular-pulmnary diseases; Hepatitis B, C or HIV infections; tumor pressure on spinal cord; Patient who will need chemo or radiotherapy during immunotherapy; 470ms=Improved QT; ECG disorders; corticosteroides administration
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: 72 hrs. Method of measurement: NCI COMMON TOXICITY CRITERIA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical and Immunological Responses. Timepoint: At least one year. Method of measurement: Flow Cytometry, Elisa, Overal Survival, Progression Free Survival. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Nowruz Delirezh
Institute of Biotechnology, Urmia University
Outcome results
None listed