The expression level alterations of some biofactors as biomarkers in response to surgery and chemotherapy in blood plasma of breast cancer patients

The expression level alterations of miRNAs 21, 155, 10b and Let-7a, and matrix metalloproteinases 1, 2, 9, 11 and 13 as biomarkers in response to surgery and chemotherapy in blood plasma of breast cancer patients

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016080818745N11

Enrollment

Registered

2016-09-04

Start date

2016-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer. Breast, unspecified

Interventions

Five ml whole blood of all patients will be collected in both stages of disease diagnosis and after the standard treatments..

Diagnosis

Five ml whole blood of all patients will be collected in both stages of disease diagnosis and after the standard treatments.

Eligibility

Sex/Gender

Female

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: The patients with breast cancer; With written informed consent; 30-70 years old patients; The breast cancer patients in stages 2 and 3. Exclusion criteria: The patients with opioid addiction; The patients with the history of rheumatoid arthritis; The patients with the history of cancer.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The alteration of plasma expression level of the miRNAs. Timepoint: before and after treatment. Method of measurement: Real-Time PCR.	—

Secondary

Measure	Time frame
The expressions of metalloproteinases level. Timepoint: befor and after treatment. Method of measurement: Gelatin quantitative zymography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Mohammad Alizadeh

Cancer Research Center, Cancer Institute of Iran

aalizadeh@sina.tums.ac.ir+98 21 6119 2501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026