Comparing the effect of electroconvulsive therapy (ECT) with or without sodium valproate on cognitive impairments and treatment response in patients with bipolar disorder with manic episode

Comparing the effect of electroconvulsive therapy (ECT) with or without sodium valproate on cognitive impairments and treatment response in patients with bipolar disorder with manic episode: a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201608049014N108

Enrollment

Registered

2016-08-14

Start date

2016-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar disorder. Bipolar affective disorder

Interventions

Intervention 1: electroconvulsive therapy three times a week for two weeks plus tablet sodium valproate 200 mg three times a day for one month. Intervention 2: electroconvulsive therapy three times a

Treatment - Drugs

Placebo

electroconvulsive therapy three times a week for two weeks plus tablet sodium valproate 200 mg three times a day for one month

electroconvulsive therapy three times a week for two weeks plus tablet placebo three times a day for one month

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: bipolar disorder with manic episode; Indication of electroconvulsive therapy. Exclusion criteria: having other psychiatric disorders; contraindication for ECT; drug abuse; using anti-convulsion medications beside sodium valproate.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cognitive impairment. Timepoint: before and one month after treatment. Method of measurement: using Minimal Mental State Exam (MMSE).;Severity of mania. Timepoint: before and one month after treatment. Method of measurement: using Young Mania Rating Scale (YMRS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHasan Golabchifard

Baharan Hospital

Dr.golabchi2016@gmail.com+98 54 3351 3777

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026