The effect of lidocaine administration during general anesthesia on inflammatory prognostic scores in breast cancer surgery candidates

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201608029593N5

Enrollment

Registered

2016-08-24

Start date

2015-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer. Breast, unspecified

Interventions

Intervention 1: After inducing anesthesia using midazolam 0.02 mg/kg, fentanyl 2-4 µg/kg, propofol 1-2 mg/kg and atracurium 0.5 mg/kg, in intervention group, 1.5 mg/kg/hr IV lidocaine was infused intr

Treatment - Drugs

After inducing anesthesia using midazolam 0.02 mg/kg, fentanyl 2-4 µg/kg, propofol 1-2 mg/kg and atracurium 0.5 mg/kg, in intervention group, 1.5 mg/kg/hr IV lidocaine was infused intravenously.

After inducing anesthesia using midazolam 0.02 mg/kg, fentanyl 2-4 µg/kg, propofol 1-2 mg/kg and atracurium 0.5 mg/kg, in control group, normal saline with the same volume and rate as 1.5 mg/kg/hr IV

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Breast cancer patients candidate for elective mastectomy;ASA class I, II Exclusion criteria: History of epilepsy; psychotic disorders; using anti-psychotic drugs; hepatic failure; elevated liver enzymes;renal failure; cardiac dysrhythmia; hospital admission more than 5 days; infection in last 14 days; drug allergic reaction to lidocaine; blood transfusion in last week; blood transfusion during or after surgery; surgery duration more than 4 hours; drug abuse are exclusion criteria

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Neutrophil to lymphocyte ratio. Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Calculation of the ratio by researcher.;Glasgow prognostic score. Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Calculation of the score by researcher.	—

Secondary

Measure	Time frame
C reactive protein. Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Based on mg/dL using laboratory kit.;Albumin. Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Based on mg/dL using laboratory kit.;Complete blood count (CBC). Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Based on count/mm3 using laboratory kit.	—

Measure

Time frame

C reactive protein. Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Based on mg/dL using laboratory kit.;Albumin. Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Based on mg/dL using laboratory kit.;Complete blood count (CBC). Timepoint: 0, 6, 24, 48 hours and 14 days after surgery. Method of measurement: Based on count/mm3 using laboratory kit.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Elham Memary

Shahid Beheshti University of Medical Sciences

drmemary@gmail.comdrmemary@sbmu.ac.ir+98 21 7755 8081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026