Gestational diabetes mellitus. Diabetes mellitus arising in pregnancy
Conditions
Interventions
Intervention 1: In the intervention group, treatment with metformin will be started with a daily dose of 500 mg and this amount will be adjusted maximally to 1500 mg in two weeks according to blood gl
Treatment - Drugs
In the intervention group, treatment with metformin will be started with a daily dose of 500 mg and this amount will be adjusted maximally to 1500 mg in two weeks according to blood glucose
In the control group, subcutaneous injection of 0.7 IU / kg insulin will be started and increased based on blood glucose recorded daily by patients.
Sponsors
Vice Chancellor for Research of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: pregnancy more than 24 weeks with gestational diabetes mellitus; singleton pregnancy; uncontrolled blood sugar with diet and exercise within a week; informed consent to participate in this project. Exclusion criteria: overt diabetes; presence of risk factors for lactic acidosis; fetal anomaly; maternal medical conditions such as kidney and liver disease; not-attending for follow up.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fast blood sugar. Timepoint: At baseline, on a daily basis until the end of pregnancy. Method of measurement: Blood sugar test / Ican glucometer, On call Model.;Blood glucose two hours after a meal. Timepoint: At baseline, on a daily basis until the end of pregnancy. Method of measurement: Blood sugar test / Ican glucometer, On call Model. | — |
Secondary
| Measure | Time frame |
|---|---|
| Type of delivery. Timepoint: Postpartum. Method of measurement: Reporting (Natural, Caesarean).;Birth weight. Timepoint: Postpartum. Method of measurement: Measuring with Germany seca Digital Scale.;Apgar score. Timepoint: Postpartum. Method of measurement: Measuring based on the standard Apgar score.;Need for NICU. Timepoint: Postpartum. Method of measurement: Reporting (have or have not). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSamaneh firouz
Mashhad University of Medical Sciences
Outcome results
None listed