Evaluation the effect of dexmedetomidine administration during surgery on intraoperative hemodynamic factors and postoperative analgesic consumption in opium addicted patients

Clinical trial of evaluation the effect of dexmedetomidine administration during femoral neck fracture surgery on intraoperative hemodynamic factors and postoperative analgesic consumption in opium addicted patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201608019593N4

Enrollment

Registered

2016-08-26

Start date

2015-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Femoral Neck Fracture. Fracture of neck of femur

Interventions

Intervention 1: Dexmetedomidine infusion at a rate of 0.5 µgr/kg/hr during surgery in intervention group. Intervention 2: Normal saline infusion with the same volume and rate of dexmedetomidine during

Treatment - Drugs

Dexmetedomidine infusion at a rate of 0.5 µgr/kg/hr during surgery in intervention group

Normal saline infusion with the same volume and rate of dexmedetomidine during surgery in control group

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 18-75; Femoral neck fracture; candidate for surgery under spinal anesthesia; history of opium abuse for at least 6 weeks Exclusion criteria: Pregnancy; breast feeding; history of chronic pain; long term analgesic use; BMI>35; diabetic; ischemic heart disease; cerebral vascular attacks; hypertension; malignancy; renal failure; hepatic failure; coagulopathy; history of drug allergy; need for blood transfusion during surgery; intolerance for spinal anesthesia

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Analgesic consumption. Timepoint: Until 24 hours after surgery. Method of measurement: Calculating the total dose of analgesic consumption by the researcher.	—

Secondary

Measure	Time frame
Pain onset. Timepoint: After finishing the surgery until first request for analgesic. Method of measurement: Time measurment by researcher based on minutes.;Hemorrhage volume. Timepoint: From the begining until the end of surgry. Method of measurement: Calculating the bleeding volume based on mililiter by researcher.;Hemodynamic side effects. Timepoint: From drug administration until end of surgry. Method of measurement: Assessing hemodynamic changes using special monitoring device.	—

Measure

Time frame

Pain onset. Timepoint: After finishing the surgery until first request for analgesic. Method of measurement: Time measurment by researcher based on minutes.;Hemorrhage volume. Timepoint: From the begining until the end of surgry. Method of measurement: Calculating the bleeding volume based on mililiter by researcher.;Hemodynamic side effects. Timepoint: From drug administration until end of surgry. Method of measurement: Assessing hemodynamic changes using special monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Elham Memary

Shahid Beheshti University of Medical Sciences

drmemary@gmail.comdrmemary@sbmu.ac.ir+98 21 7755 8081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026