Evaluation the effect of complementary treatment with pistacia atlantica mouthwash on chemotherapy-induced mucositis

Evaluation the effect of complementary treatment with pistacia atlantica mouthwash on chemotherapy-induced mucositis (a double blind randomized placebo controlled clinical trial)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160731029133N5

Enrollment

Registered

2018-01-30

Start date

2018-01-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: chemotherapy-induced mucositis. Condition 2: Xerostomia. Oral mucositis (ulcerative) Disturbances of salivary secretion

Interventions

Intervention 1: The members of the experimental group have to use Pistacia Atlantica mouthwash in addition to that basic treatment.This mouthwsh consists of: Humectant 5-20%(Glycerine-Sorbitol- propyl

Treatment - Drugs

Placebo

The members of the experimental group have to use Pistacia Atlantica mouthwash in addition to that basic treatment.This mouthwsh consists of: Humectant 5-20%(Glycerine-Sorbitol- propylene glycol),Surf

The members of the control group have to use placebo in addition to basic treatment,to eliminate mental effects.(However they shoudn't know that this mouthwash is just a placebo.) Placebo consists of

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1-Existence of chemotherapy-induced mucositis. 2-Participates must be at least 18 years old. 3-Not existence of serious dental problems or traumatic teeth or sharp-pointed cusps or fillings. 4-Not using of traumatic dentures. 5-Not using of anti-inflammatory agents or other mouthwashes during the study. 6-Absence of other systemic disease

Exclusion criteria

Exclusion criteria: 1-Patients' inability to do the instructions of the protocol of the study. 2-Patients' death because of not responding to the cancer treatment. 3-Complementary treatments such as radiotherapy. 4-The history of allergy to pistacia atlantica. 5-The history of usage of cigarette,narcotics and alcohol.

Design outcomes

Primary

Measure	Time frame
Severity of oral mucositis. Timepoint: Before intervention, 3 days after beginning of the intervention, 7 days after beginning of the intervention(the last day of the intervention). Method of measurement: WHO scoring system.;Severity of xerostomia. Timepoint: Before intervention, 3 days after beginning of the intervention, 7 days after beginning of the intervention(the last day of the intervention). Method of measurement: Lickert's method.	—

Measure

Time frame

Severity of oral mucositis. Timepoint: Before intervention, 3 days after beginning of the intervention, 7 days after beginning of the intervention(the last day of the intervention). Method of measurement: WHO scoring system.;Severity of xerostomia. Timepoint: Before intervention, 3 days after beginning of the intervention, 7 days after beginning of the intervention(the last day of the intervention). Method of measurement: Lickert's method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Neda Gholami

Zanjan University of Medical Sciences

dr.gholami.n@zums.ac.ir+98 24 3347 1118

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026