Coronary artery disease. Ischaemic heart diseases
Conditions
Interventions
Intervention 1: In the intervention group before the start of cardiopulmonary bypass and After the arterial cannulation by the surgeon we allow the patient blood reversely enter in arterial line by ao
Treatment - Other
Treatment - Drugs
In the intervention group before the start of cardiopulmonary bypass and After the arterial cannulation by the surgeon we allow the patient blood reversely enter in arterial line by aorta pressure And
In the control group cardiopulmonary bypass circuits primed with conventional method (approximately1500 ml of crystalloid and colloid).And this fluid volume remains in the cardiopulmonary bypass circu
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: adult patients undergoing coronary artery bypass surgery using cardiopulmonary bypass; no history of past heart surgery; age older than 18 and less than 70 years old; hemoglobin level greater than 8.5 and less than 14; body weight more than 45 kg and less than 100 kg; left ventricular ejection fraction greater than 25%. Exclusion criteria: history of cardiac surgery; the patient or the patient's family withdraw from the study during the intervention period; emergency surgery; severe infection; clotting problems before surgery (INR> 1.2, aPTT> 40 s and blood platelet count less than 100 thousand per cubic meter); danapyroid and Lepyrudyn and dabigatran drug in the month before the operation; use Hemofilter and Cell Saver; the use of preoperative mechanical ventilation; dialysis before surgery; the existence of liver failure as (AST> 40 unit / L) and ((ALT> 40 unit / L before surgery.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in arterial blood gases. Timepoint: Before anesthesia, intraoperative and postoperative. Method of measurement: content of each gas in arterial blood Under the pressure of eac gas.;The need for blood and blood products transfusions during surgery. Timepoint: During Surgery. Method of measurement: The number of bags of blood and blood products in terms of unit.;The amount of postoperative blood and blood product transfusion. Timepoint: After surgery and during the hospitalization. Method of measurement: The number of bags of blood and blood products.;Duration of mechanical ventilation connection. Timepoint: During the intensive care unit. Method of measurement: Duration of mechanical ventilation connection based on hours.;Ejection fraction. Timepoint: After surgery in ward. Method of measurement: Ratio between strok volume to end diastolic volume according to percent. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin - Hematocrit. Timepoint: During the operation, 12,24 and 48 hours after surgery. Method of measurement: The amount of hemoglobin according to milligrams per deciliter and hematocrit according percent. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMusa Rafiee Vardanjany
Iran University of Medical Sciences
Outcome results
None listed