Skip to content

Clinical trial effect of midazolam and ondansetron on nausea and vomiting in parturient under cesarean with spinal anesthesia

Comparison the effect of intravenous midazolam and ondansetron on nausea and vomiting in cesarean sections with spinal anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016073027677N2
Enrollment
126
Registered
2016-10-19
Start date
2015-10-24
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nausea and vomiying in cesarean. Vomiting of pregnancy, unspecified

Interventions

Intervention 1: Intervention group 2: Midazolam (Tehran Chemie) (2mg) will be prepared in 5 cc syringes and after closing cord randomly injected. Intervention 2: Intervention group 3:Midazolam (2mg) a
Prevention
Intervention group 2: Midazolam (Tehran Chemie) (2mg) will be prepared in 5 cc syringes and after closing cord randomly injected.
Intervention group 3:Midazolam (2mg) and Ondansetron (Tehran Chemie) (4mg) will be prepared in 5 cc syringes and after closing cord randomly injected.
Intervention group 2: Ondansetron (Tehran Chemie) (4mg) will be prepared in 5 cc syringes and after closing cord randomly injected.

Sponsors

Urmia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Pregnant women aged between 20 and 40 years old; american society of anesthesiologists class 1 and 2; cesarean with spinal anesthesia Exclusion criteria: Patients with a history of gastrointestinal disease; smokers; Motion sickness; Allergies to medicines; Previous history of nausea and vomiting during anesthesia; Preeclampsia, Eclampsia; patients who have used anti-nausea drug in the past 24 hours.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Nausea and vomiting. Timepoint: during and after surgery in recovery. Method of measurement: patient observation.

Secondary

MeasureTime frame
Blood pressure. Timepoint: During operation every 3 minutes after drug injection. Method of measurement: none invasive blood pressure.;Pulse rate. Timepoint: During operation every 3 minutes after drug injection. Method of measurement: Electrocardiogram.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahryar Sane

Urmia University of Medical Sciences

sane.sh@umsu.ac.ir; shahryarsane@yahoo.com; dr.sh.sane@gmail.com+98 44 3222 4777

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026