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Comparing fluid therapy for kidney transplant surgery guided by PVI (Plethysmography Variability Index) monitoring and conventional fluid therapy in improving transplant kidney function

Comparing fluid therapy guided by PVI (Plethysmography Variability Index) monitoring vs. conventional fluid therapy in improving transplant kidney function and blood lactate levels in kidney transplant patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016072929116N1
Enrollment
50
Registered
2016-12-07
Start date
2015-09-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End Stage Renal Failure. End stage kidney disease on dialysis

Interventions

Intervention 1: In the intervention group we use PVI monitoring (plethysmography variablility index) to administer fluids during kidney transplantation surgery. We use the Masimo set PVI monitoring. M
Treatment - Other
In the control group we administer fluids to the patients by the conventional liberal methods for transplant recipient patients. we give fluids freely to compensate for hemodynamic abnormalities and/o
In the intervention group we use PVI monitoring (plethysmography variablility index) to administer fluids during kidney transplantation surgery. We use the Masimo set PVI monitoring. Masimo, Irvine C

Sponsors

Vice Chancellor for research of Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Kidney transplant recipients between 18 and 70 years old who are not cases of known cardiomyopathy; AF rhythm; Blood tranfusion during surgery; History of valve replacement surgery; History of asthma or chronic obstructive pulmonary disease; Morbid obesity; EF<40%, Hb<7; Symptomatic coronary artery diseasse; Prior kidney transplantation history; Exclusion criteria: peri-operative arrhythmias; peri-operative blood loss more than 1000cc;

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Urine Volume. Timepoint: Before and after aortic declamping, 2hours after surgery, The day after surgery, 6 months after surgery. Method of measurement: Reading the Urine bag value.;Serum Lactate. Timepoint: Before and after aortic declamping, 2hours after surgery, The day after surgery, 6 months after surgery. Method of measurement: Arterial Blood Gas sample.

Secondary

MeasureTime frame
Serum creatine. Timepoint: before surgery, The day after surgery. Method of measurement: Biochemistry Lab test.;Blood Urea Nitrogen. Timepoint: before surgery, The day after surgery. Method of measurement: Biochemistry Lab test.;Arterial Blood Gas (ABG). Timepoint: before surgery, before and after aortic declamp, 2hours after surgery, The day after surgery. Method of measurement: Arterial Blood Gas sampling.;Heart Rate per minute. Timepoint: before surgery, before and after aortic declamp, 2hours after surgery, The day after surgery. Method of measurement: Pulse oximetry.;Blood Pressure (Mean Arterial Pressure). Timepoint: before surgery, before and after aortic declamp, 2hours after surgery, The day after surgery. Method of measurement: Non Invasive Blood Pressure monitoring.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFardad Iranidoost Haghighi

Tehran University Of Medical Sciences

drfardad@Gmail.comf-iranidoosth@TUMS.ac.ir+98 21 2235 2772

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026