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Comparison of antibiotic treatment regimens in the treatment of pregnant women cystitis

A comparative study of single dose versus 3 days regime of Ampicillin, Ccephalosporin, and Nitrofurantoin in treatment of Cystitis in pregnancy reffered to Imama Reza Hospital.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016072814333N54
Enrollment
246
Registered
2016-08-26
Start date
2016-08-15
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy. Supervision of other normal pregnancy

Interventions

Intervention 1: In the first group, treated will be done with penicillin single dose (2 g). Intervention 2: The fifth experimental group Nitrofurantoin single dose (200 mg) will given. Intervention 3:
Treatment - Drugs
In the first group, treated will be done with penicillin single dose (2 g).
The fifth experimental group Nitrofurantoin single dose (200 mg) will given
In the second group, three-day treatment will be done with Ampicillin (250 mg) and will given antibiotics every 6 hours.
The third experimental group will receive single dose of cephalosporin (2 g)
Fourth experimental group will receive three-day cephalosporin (250 mg) and will given antibiotics every 6 hours.
Sixth experimental group will receive three-day Nitrofurantoin (100 mg) and will given antibiotics every 6 hours.

Sponsors

Vice chancellor for research, Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1 gravidity women; Age 35-20 years; No history of systemic diseases and certain medications; Gestational age above 20 weeks and singleton pregnant with cystitis symptoms (dysuria who, frequent urination, suprapubic pain, polyuria); Patients who UA and UC tests will carried out for them and bacteriuria and pyuria will reported for them. Exclusion criteria: Pregnant women with complicated pregnancy or access to them is not possible; Chronic and incurable diseases or blood diseases, liver or diabetic; Patients who have taken antibiotics in the past three weeks, or history of positive kidney disease and bladder; Pregnant women with symptoms of fever, chills, CVA and signs of pyelonephritis or are sensitive to the study antibiotics.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pregnancy cystitis. Timepoint: Beginning of the study, 7 to 10 days after completion of treatment. Method of measurement: Based on the experimental results.

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026