The effect of vitamin C on lymphocyte apoptosis induced by radiation

Evaluating the effect of vitamin C on apoptosis compared to control group on apoptosis in peripheral blood lymphocytes in patients treated with ablation in cardiac electrophysiology studies

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016072529068N1

Enrollment

Registered

2016-09-19

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients treated with ablation in cardiac electrophysiology studies. Atrial fibrillation and flutter, Paroxysmal tachycardia

Interventions

Intervention 1: Vitamin C (ascorbic acid), 1 gram oral tablet, only once in 3 hours prior to the test. Intervention 2: Vitamin C (ascorbic acid), 2 gram oral tablet, only once in 3 hours prior to the

Prevention

Vitamin C (ascorbic acid), 1 gram oral tablet, only once in 3 hours prior to the test

Vitamin C (ascorbic acid), 2 gram oral tablet, only once in 3 hours prior to the test

The control group without action

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Non-smoking; Lack of infectious disease; Do not use of antibiotics; Unexposed to ionizing radiation, 24 hours prior to sampling Exclusion criteria: Use of multivitamins; Use of alcohol; Acute or chronic disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Apoptosis. Timepoint: Before the intervention and after intervention within 24 hours after the test. Method of measurement: Counting the number of apoptotic peripheral blood lymphocytes by flow cytometry.	—

Secondary

Measure	Time frame
Bax protein. Timepoint: Before intervention and after intervention within 24 hours after the test. Method of measurement: Counting the number of Bax protein by ELISA method.;Bcl-2 protein. Timepoint: Before intervention and after intervention within 24 hours after the test. Method of measurement: Counting the number of Bcl-2 protein by ELISA method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamHasan Hadadi

Shiraz University of Medical Sciences

ghadadi@gmail.com ; hashemib@sums.ac.ir+98 71 3230 5415

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026