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Compare the effects of oral supplementation carob, curcumin plants and Propolis supplements on sperm parameters, some inflammatory factors and sex hormone levels in men with idiopathic infertility

Compare the effects of oral supplementation carob, curcumin plants and Propolis supplements on sperm parameters, some inflammatory factors and sex hormone levels in men with idiopathic infertility: randomized double blind clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016072519669N2
Enrollment
80
Registered
2016-09-09
Start date
2016-08-10
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthenospermia. male infertility

Interventions

Intervention 1: Control group:Placebo placebo: Lactose, 12 weeks, 3 capsule(500 mg) per day. Intervention 2: Curcumin acid 80 mg per day for 12 weeks, 2 capsule per day(40 mg). Intervention 3: Interve
Placebo
Treatment - Drugs
Control group:Placebo placebo: Lactose, 12 weeks, 3 capsule(500 mg) per day
Curcumin acid 80 mg per day for 12 weeks, 2 capsule per day(40 mg)
Intervention group:carob 500 mg per day for 12 weeks, 3 capsule per day(500 mg)
Intervention group:Propolis acid 600 mg per day for12 weeks, 3 capsule per day(500 mg)

Sponsors

Deputy for Research Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
25 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Willing to participate in the study ; Passing at least a year since the decision to child bearing (no conception after 12 months intercourse without any contraception); age 20-45 y.o; idiopathic asthenospermia according to WHO criteria; normal levels of gonadotropins , testosterone and prolactin. Exclusion criteria: any infection in genitourinary (GU) tract; any anatomical abnormality in GU tract such as varicocele , cryptorchidism; any chronic disease during last 3 months; any surgery on the testes and vas deferens; patients undergoing ICSI due to severe impairment sperm quality and the presence of other infertility factors, contact with pesticides, heavy metals and solvents; consumption of antioxidant supplements during last 3 months.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Sperm motility. Timepoint: The beginning of the study , End of the study. Method of measurement: spermatogram.

Secondary

MeasureTime frame
Sex hormones. Timepoint: 12 weeks. Method of measurement: Eliza.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hossein Khadem Haghighian

Qazvin University of Medical Sciences

khademnut@yahoo.com+98 28 3732 7650

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026