The incidence of cardiac arrhythmia in coronary artery bypass surgery

comparison the effectiveness of dexmedetomidine with midazolam on incidence of cardiac arrhythmia in off-pump coronary artery bypass surgery patients, a clinical trial.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016072413159N9

Enrollment

Registered

2016-07-30

Start date

2016-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiopulmonary bypass. Pulmonary heart disease, unspecified

Interventions

Intervention 1: Control group: Patients are receiving 0.5 mg/kg midazolam addition of 10 mcg/kg fentanyl, 0.5 mg/kg atracurium, and 1.5 mg/kg propofol for induction of anesthesia. Cardiac arrhythmia r

Treatment - Drugs

Control group: Patients are receiving 0.5 mg/kg midazolam addition of 10 mcg/kg fentanyl, 0.5 mg/kg atracurium, and 1.5 mg/kg propofol for induction of anesthesia. Cardiac arrhythmia rate and hemodyna

Interventional group: Patients are receiving 1 mcg/kg dexmedetomidine infusion for induction of anesthesia for 10 minutes, and then infusion is fallowing up with 0.2 to 0.6 mg/kg/h based on tolerance

Eligibility

Sex/Gender

All

Age

30 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients undergoing off-pump coronary artery bypass surgery; sustaining ASA I and ASA II; aged between 18-75 years; EF more than 35%. Exclusion criteria: History of arrhythmias or heart block; EF less than 35%; history of cardiac surgery; history of valvular heart disease; having left atrial enlargement (LAE) or cardiomegaly.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cardiac arrhythmia rate. Timepoint: During and 24 hours after surgery. Method of measurement: Heart monitoring.	—

Secondary

Measure	Time frame
Hemodynamic changes. Timepoint: During and 24 hours after surgery. Method of measurement: Heart monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShima Shebani

Mashhad University of Medical Sciences

sheybanish@mums.ac.ir+98 51 3801 2612

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 8, 2026