Carbon monoxide poisoning. Toxic effect of carbon monoxide
Conditions
Interventions
Intervention 1: Granulocyte colony-stimulating factor (G-CSF) at dose 180 µg / Kg, one-third of the total dose as a loading dose within 20 minutes and the remaining two-thirds dose for continuous infu
Treatment - Drugs
Placebo
Granulocyte colony-stimulating factor (G-CSF) at dose 180 µg / Kg, one-third of the total dose as a loading dose within 20 minutes and the remaining two-thirds dose for continuous infusion at a consta
100 ml of sodium chloride isotonic injection of a third of the total dose as the dose loading within 20 minutes, and two-thirds of the remaining dose for continuous infusion at a constant rate over 72
Sponsors
Management and technology assistance of Mashhad university of medical sciences, school of pharmac
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: diagnosis of carbon monoxide poisoning based on clinical and laboratory findings; poisoning severity of moderate to severe based on the concentration of carboxyhemoglobin and clinical symptoms (NIHSS); poisoned patients must be enrolled within 24 hours of incidence of toxicity; Age between 18 and 70 years Exclusion criteria: Pregnancy; Other Simultaneous poisoning; Burn; the history of neurosurgical and head trauma During the past 4 weeks; multiple trauma 6 - ischemic stroke or hemorrhagic during the last 4 weeks; Malignancies; chronic inflammatory diseases; hematologic malignancies; allergies and or elevated titers of antibodies against erythropoietin and high blood pressure180/110; cardiovascular disease; any previous cerebrovascular lesions
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| S100B serum concentration. Timepoint: Day 1 pre-intervention, 3 and 30 after intervention. Method of measurement: Elysa kit.;NIHSS. Timepoint: Day 1 pre-intervention, 3 and 30 after intervention. Method of measurement: NIHSS scor chart.;Barthel Index. Timepoint: Day 30 after intervention. Method of measurement: Barthel Index chart.;TI serum concentration. Timepoint: In 3,12, 24, 48 and 72 houers after intervention. Method of measurement: Elysa kit.;Cardiac arrhythmias. Timepoint: During 24 h after intervention. Method of measurement: ECG holter monitor. | — |
Secondary
| Measure | Time frame |
|---|---|
| G-CSF serum concentration. Timepoint: in times 0.5, 1, 2, 5, 8, 12, 24, 48 h after intervention. Method of measurement: elysa kit.;Vital signs: BP, HR, T and RR. Timepoint: Every 4 hours during the first 24 hours, every 6 hours during the second and third days. Method of measurement: By nurse.;Modified Rankin score. Timepoint: In day 30 after intervention. Method of measurement: Modified Rankin score chart.;Carboxyhemoglobin serum concentration. Timepoint: In Day1 (pre-intervention), 3 and 30 after intervention. Method of measurement: GC-mas-mas Headspace.;Glial Fibrilary Acidic protein(GFAP) serum concentration. Timepoint: Day1 (pre-intervention), 3 and 30 after intervention. Method of measurement: Elysa kit.;Myeloperoxidase serum concentration. Timepoint: Day1 (pre-intervention), 3 and 30 after intervention. Method of measurement: Elysa kit.;Myelin basic protein. Timepoint: Day1 (pre-intervention), 3 and 30 after intervention. Method of measurement: Elysa kit.;Cerebral ischemia. Timepoint: Day1 (pre-intervention), 3 and 30 after intervention. Method of measurement: Brain MRI.;Headache, asthenia, memory impairment, sleep disorders, trouble concentrating, visual disturbances and behavioral disorders. Timepoint: Day1 (pre-intervention), 3 and 30 after intervention. Method of measurement: By specialist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Seyed Reza Mousavi
Mashhad University of Medical Sciences
Outcome results
None listed