Effects of platelet rich plasma on frozen embryo transfer process

Effects of autologous platelet rich plasma on endometrial growth and implantation in intracytoplasmic sperm injection cycles: clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016072229027N1

Enrollment

Registered

2016-09-05

Start date

2015-12-16

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Noninflammatory disorders of female genital tract. Complication associated with artificial fertilization, unspecified

Interventions

Intervention 1: Intervention group: Intrauterine infusion of 0.5 ml platelet rich plasma (PRP) that contained platelet 4-5 times more than peripheral blood with uterine catheter is performed if endome

Treatment - Other

Placebo

Intervention group: Intrauterine infusion of 0.5 ml platelet rich plasma (PRP) that contained platelet 4-5 times more than peripheral blood with uterine catheter is performed if endometrial thickness

Control group: Dummy catheter (sham catheter) is performed if endometrial thickness below 7 mm on day 13-14 of cycle and the procedure is repeated 48 hours later if the endometrial thickness below 7 m

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Body mass index (BMI) below 30; unadequate endometrium (endometrial thickness below 7 mm); history of hematologic disease3 failed embryo transfer Exclusion criteria: history of hematologic disorders; uterine abnormality (acquired or congenital); unwillingness to continue

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: Transvaginal ultrasound.;Chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: Serum BHCG.;Endometrial thickness. Timepoint: 48 hours after PRP. Method of measurement: The most ndometrial thickening in transvaginal ultrasound.	—

Secondary

Measure	Time frame
Ongoing pregnancy. Timepoint: 10 weeks after embryo transfer. Method of measurement: Fetal heart beat in ultrasound.;Abortion. Timepoint: Before 20 weeks of pregnancy. Method of measurement: Fetal demise before 20 weeks of gestation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeila Nazari

Shahid Beheshti University of Medical Sciences

nazari@sbmu.ac.ir+98 21 2243 2558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026