The effects of different doses of dexamethasone on pain management in orthopedic surgery

Comparing the effect of adding different doses of dexamethason to fentanil in patient control analgesia after lower limb orthopedic surgeries

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016071928996N1

Enrollment

102

Registered

2016-10-23

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain. fracture of upper end of tibia , fracture of shaft of tibia , fracture of lower end of tibia

Interventions

Intervention 1: The control group: received intravenous pain pump contains 1 mg of fentanyl with 10 mL of saline. Intervention 2: The second group: received fentanyl-containing pain pumps plus 8 mg de

Treatment - Drugs

The control group: received intravenous pain pump contains 1 mg of fentanyl with 10 mL of saline

The second group: received fentanyl-containing pain pumps plus 8 mg dexamethasone. Both drugs are making in Aburaihan pharmaceutical company.

The second group received fentanyl-containing pain pumps plus 16 mg dexamethasone. Both drugs are making in Aburaihan pharmaceutical company.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: inclusion criterias: patients with age 18 to 60 years old; patients under the lower limb orthopedic surgeries; patients with ASA class 1 or 2; patient"s satisfaction exclusion criterias:allergy to dexamethasone or other corticostroides; addiction to opioeds or alchol and any drug abuse; affiction to peptic ulcer disease, renal or adrenal desease , osteopenia , osteoprosis; uncontroled HTN; ASA class > 2; pregnancy or breast feeding; corton therapy; NSAID therapy; Patients with platelet disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 0 , 2 , 6 , 12 , 24 hrs after intervention. Method of measurement: VAS.	—

Secondary

Measure	Time frame
Analgesic consumption rate. Timepoint: 0,2.6.12.24 hrs after intervention. Method of measurement: dosage rate.;Nausea and vomiting. Timepoint: 0,2,6,12,24 hrs after the intervention. Method of measurement: Postoperative nausea and vomiting score.;Blood presure. Timepoint: 0,2,6.12.24 hrs after the intervention. Method of measurement: manual mercuric pressure guage (mmHg).;Heart rate. Timepoint: 0,2,6,12,24 hrs after the intervention. Method of measurement: Manual : bpm (Beats Per Minute).	—

Measure

Time frame

Analgesic consumption rate. Timepoint: 0,2.6.12.24 hrs after intervention. Method of measurement: dosage rate.;Nausea and vomiting. Timepoint: 0,2,6,12,24 hrs after the intervention. Method of measurement: Postoperative nausea and vomiting score.;Blood presure. Timepoint: 0,2,6.12.24 hrs after the intervention. Method of measurement: manual mercuric pressure guage (mmHg).;Heart rate. Timepoint: 0,2,6,12,24 hrs after the intervention. Method of measurement: Manual : bpm (Beats Per Minute).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Nabipour Asri

Ardabil University of Medical Sciences

f.nabipour@arums.ac.ir+98 45 3351 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026